PHRG 5230 - The Organic Chemistry of Drug Design and Drug Action (3)
Prerequisites: Organic Chemistry, Biochemistry or with the consent of the instructor. The success in drug design is dependent on insights and advances from the combined use of chemical and biological investigation. The goal of this course will be to educate students in drug design and drug action. This course will provide students with the opportunity to learn why drug-receptor interactions are important to drug efficacy, understand the mechanisms of drug chemistry, identify the pharmacophore of a target structure, examine structural modification to increase potency (SAR), become familiar with computational approaches used in the drug design, and learn how medicinal chemists approach resolving problems of metabolic destruction of drugs.
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